1304-1305 / 2001
Normal tissue effects and injury
LDR prostate brachytherapy u
‐
Acute effects
symptoms
helium Inflammation,
oedema,
hyperaemia
irritative and obstructive –
•
Burning
•
urgency
,
cellular loss with
loss of epithelial
integrity
•
frequency
•
nocturia
•
urge incontinence
•
urinary retention
•
haematuria
•
spasmodic pain
– Acute effects
rothelium
outcome
management
•
Mostly self‐limiting
•
Resolves
spontaneously
Supportive
Reassurance
Pharmacological –
•
Symptoms subside
gradually as radiation
diminishes.
•
NSAID
•
Cortisone
•
cholinergic agonists
•
Typically takes
6‐12 months
•
Do not generally
•
alpha‐adrenergic blocking
agents
•
anticholinergic agents
convey risk of late
complications
•
tricyclic antidepressants
(TCAs)
•
sympathomimetic agents
•
Dr Stone’s urethral
instillation formula
Catheterization for retention