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Sildenafil Restores Erection Hardness (ICP)

Sildenafil

l

80

100

ICP

Reduced

ICP

Restored

Hg

40

60

ICP, mm

0

20

200

Nerve stim

60s

100

ow, ml/min

C ff

C ff

0

Blood Fl

• Penile blood flow restriction reduces cavernous nerve-stimulated increases in ICP

• Sildenafil restores erection hardness to control levels

u

u

Wayman C et al. ESSM. 4-7 December 2005. Poster M-05-141.

Preclinical model