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Printing of this thesis was financially supported by the department of intensive care and
paediatric surgery, Sophia Children’s Hospital-Erasmus MC, Rotterdam; InstruLabo BV (www.
instrulabo.nl)& Brunschwig Chemie
(www.brunschwig.nl)and:
The studies described in this thesis were (partially) supported by Fonds NutsOhra; Erasmus
MC Cost-Effectiveness Research Grant (Mrace); Erasmus Trustfonds via Erasmus University
Rotterdam; the Flemish Agency for Innovation through Science and Technology (IWT-
TBM110685); the Methusalem Program funded by the Flemish Government (METH/08/07 and
METH/14/06); the European Research Council under the European Union’s Seventh Framework
Programme (FP7/2007-2013)/ERC Advanced Grant Agreement n° 307523.
©2016, D. Kerklaan, The Netherlands, 2016
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or
transmitted in any formby anymeans, without prior written permission of the copyright owner.
ISBN: 978-94-6233-289-8
Cover and graphic design: Robin Kerklaan
Printing: Gildeprint, The Netherlands