49
50
Figure 1: Chemical structure of the most abundant repetitive disaccharide unit in a chondroitin
51
sulfate chain. Chondroitin-4-sulfate: R1 = H; R2 = SO3H; R3 = H. Chondroitin-6-sulfate: R1 = SO3H;
52
R2, R3 = H. Chondroitin sulfate has also a linkage region to consisting of GlcAβ-1-3Galβ-1-3Galβ-
53
1-4Xylβ-1-O-Ser, and a capping trisulfated monosaccharide. Commercial chondroitin sulfate has a
54
varying content of non-sulfated disaccharides and it may contain some degree of
55
decarboxylation depending on the isolation and purification treatment. Sulfation position
56
depends on the species from which it is derived, age of the animals and anatomic location of the
57
cartilage.
58
59
60
Dietary Ingredients
61
A vitamin; a mineral; an herb or other botanical; an amino acid; a dietary substance for use
62
by man to supplement the diet by increasing total dietary intake; or a concentrate,
63
metabolite, constituent, extract, or combination of any of the above dietary ingredients
64
65
Dietary supplements
66
A product intended for ingestion that contains a "dietary ingredient" intended to add
67
further nutritional value to (supplement) the diet. Dietary supplements may be found in
68
many forms such as tablets, capsules, softgels, gelcaps, liquids, or powders.
69
70
Laboratory Probability of Detection (LPOD)
71
The POD value obtained from combining all valid collaborator data sets for a method for a
72
given matrix at a given analyte level or concentration. LPOD
(0)
= the LPOD at 0
73
concentration of the target microorganism. (AOAC)
74
75
Probability of Detection (POD)
76
The proportion of positive analytical outcomes for a qualitative method for a given matrix at
77
a given analyte level or concentration.
78
79
FDA.
3
Appendix H: Probability of Detection (POD) as a Statistical Model for the Validation of Qualitative Methods,
Official Methods of Analysis of AOAC INTERNATIONAL, 19
th
edition, 2012.
2
