Overview: 4 Cohorts
Cohort # of pts
Induction Chemotherapy
If PET-4 negative, then…
1
30
BV+AVD x 4 cycles
30 Gy ISRT
2
29
BV+AVD x 4 cycles
20 Gy ISRT
3
29
BV+AVD x 4 cycles
30 Gy ConsolidationVolume
Radiotherapy (CVRT)
4
29
BV+AVD x 4 cycles
No further treatment
Multicenter collaboration
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MSKCC, University of Rochester, Stanford University, City of Hope