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13-034 Cohort 4 Study Design

Brentuximab (1.2 mg/m

2

)+ AVD x 2 cycles

PET-CT-2

PET-CT-4

Biopsy

Bx-

Bx+

No RT

Off study

Brentuximab (1.2 mg/m

2

)+ AVD x 2 cycles

Eligiblity:

Histologically confirmed cHL

Stage I or II

Bulky mediastinal mass (≥7cm in

MTD or MCD)