1698 / 1835
Cytologically resembles many
other large B cell lymphoma
Large transformed cells
resembling centroblasts
Abundant pale cytoplasm
Diffuse involvement
marked areas of fine
compartmentalising sclerosis
Pathology
Expression of B-cell antigens:CD20 and CD79a positive, but lack sIg
CD30 may be present (>80%) although typically weak CD23: Frequent (73%)
BCL2: variable (50-80%, no t(14;18)
BCL6: variable (45-100%)
CD10: less common (8-30%)
Present: MAL (70%) – normal expression in thymic medullary cells, CD54,
CD95, nuclear REL, TRAF
Evidence of somatic hypermutation