1747 / 1835
Change of RCHOP in DLBCL
Study
Pt no
iPET timing
Intervention
End point
Pradal
(GELTAMO)
2015
71
>3 cycles
MegaCHOP
-ve: 3 MegaRCHOP
+ve: 2 RICE +
BEAM ASCT
(no info on RT)
3y PFS: -ve: 81%, +ve: 57%
OS: -ve: 95%, +ve 33%
Swinnen
(ECOG) 2014
74
> 3 RCHOP
-ve: 3 RCHOP
+ve: 4
RICE
(no RT)
2y PFS -ve: 76%, +ve: 42%
OS -ve: 93%, +ve 69%
Duehrsen
(PETAL)
2014
853
(926)
> 2 RCHOP
-ve: randomise to 4 RCHOP or
4 RCHOP + 2R
+ve: randomise to 4 RCHOP or
intensification
2 R: no difference
(HR 1.2, 95%CI 0.8-2.1)
Intensification: no difference
(HR 1.6, 95%CI 0.9-2.7)
Sehn (BCCA)
2014
155
> 4 RCHOP
-ve: 2 RCHOP
+ve: 4
RICE
+ RT for EOT PET
+ve
4y PFS -ve: 91%, +ve: 59%
OS -ve: 96%, +ve 73%
Kasamon
2009
59
> 2-3
RCHOP
-ve: continue RCHOP
+ve: 2
ESHAP
or
ICE
+ ASCT
RT permissible
2y EFS -ve: 89%, +ve: 67%