1750 / 1835
Points for discussion
•
Bx
was not done: course of disease (PET-2, PET-4, PET-6) + increase in size.
•
Aim was to get
CMR
(-ve PET) prior to ASCT.
•
Expected
salvage chemo alone
is not adequate:
–
Bulky disease
–
Primary refractory
–
CORAL data re poor salvage-ability >R
•
response rate 51% v 83%
•
3y EFS of 21% v 47%
•
Primary refractory disease worse
•
Retrospective evidence of benefit of
peri-transplant RT
, particularly after R
•
Concern about
pneumonitis
?