200 / 1835
HD11: Long-term Outcome
Inferior 10-year PFS with 20Gy IF-RT
instead of 30Gy after 4x ABVD
No difference after 4x BEACOPP
base
No difference regarding 10-year OS
356
350
10 year estimate [95%-CI] Hazard Ratio [95%-CI]
ABVD+30Gy
90.9% [87.5% to 94.2%]
ABVD+20Gy
89.5% [86.1% to 93.0%]
1.2 [0.7 to 1.9]
BEAbase+30Gy 90.5% [87.2% to 93.9%]
1.0 [0.6 to 1.7]
BEAbase+20Gy 91.4% [88.2% to 94.7%]
1.0 [0.6 to 1.7]
Median observation time 117 months
332
315
10 year estimate [95%-CI] Hazard Ratio [95%-CI]
BEAbase+30Gy 84.0% [79.6% to 88.4%]
BEAbase+20Gy 83.7% [79.2% to 88.3%]
1.0 [0.7 to 1.5]
Difference
-0.3% [-6.6% to 6.0%]
Median observation time 108 months
PFS
BEACOPP
base
OS
343
332
10 year estimate [95%-CI] Hazard Ratio [95%-CI]
ABVD+30Gy
83.9% [79.4% to 88.3%]
ABVD+20Gy
75.6% [70.3% to 80.9%]
1.5 [1.0 to 2.1]
Difference
-8.3% [-15.2% to -1.3%]
Median observation time 105 months
PFS ABVD