2016 Hematological Malignancies

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Dose Density: UK R-CHOP14 vs. 21

Cunningham, D,

et al. Lance

t 2013; 381:1817–1826.

Newly

diagnosed

CD20+ve

DLBCL

R-CHOP21

CHOP21

×

8 cycles

Rituximab

×

8 cycles

R-CHOP14

CHOP14

×

6 cycles

Rituximab

×

8 cycles

Lenograstim Day 4-12

n=540

n=540

Stratified by

• IPI (0-1, 2, 3, 4-5)

• Age

≤60 vs.

>60

• Treatment centre

1080 patients; 119 sites

Recruitment March 2005 - Nov 2008

R