583 / 1835
But how to distinguish phenotype?
Hans, C. P. et al. Blood 2004;103:275-282
►
Getting it right is important when
looking prospectively at therapy, not
prognosis
►
The immunophenotype is not that
good:
►
CD10+ (about 1/3), Mum-1-: Almost all
GCB
►
CD10- (2/3) hard to distinguish ABC
from GCB on immuno’s
►
Bcl-6 is a difficult stain
►
Discordance with mRNA (~20%)
►
Conflicting IHC datasets
►
Lunenberg project demonstrates poor
correlation between centres (technical
and interpretative)