591 / 1835
0,0%
5,0%
10,0%
15,0%
20,0%
25,0%
30,0%
35,0%
ABC subtype
GCB subtype
Unclassified
Gene mutations vs subtype (n=191)
•
73% have a mutation detectable in 1 or more genes (range 0-5)
•
MYD88 was most commonly mutated (in 30% of ABC and 7% of GCB).
•
EZH2 mutations were restricted to the GCB category (26%)
•
MYD88, CD79a/b and PRDM1 were more commonly associated with ABC.
•
Where MYD88 was seen in GCB cases, coexisting mutations imply an origin from
transformed follicular lymphoma.
•
B2M mutations were commonly identified across all subtypes, but specifically
enriched in Type III (unclassified) cases (25%)
Barrans et al. ASH 2015