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What about the GCB Phenotype?
McCabe M T et al
. Proc Nat Acad Sci USA
2012;109:2989-2994
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Enhancer of Zeste 2 (EZH2) is the
enzyme component of the Polycomb
Repressive Complex 2 (PRC2) that
methylates histone H3 on lysine 27
(H3K27)
►
Somatic activating mutations in EZH2
have been identified in follicular and
GCB-DLBCL
[Morin, 2010; Morin, 2011;
Pasqualucci, 2011];
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The frequency of the most prevalent
mutation, Y641, 22% in DLBCL.
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Inhibitors in early phase investigation