606 / 1835
Exhausted T-Cells and Checkpoint blockade
therapy
►
Important interplay between
malignant cells and
microenvironment.
►
…eventually ineffective. Immune
escape or immune checkpoints
►
Blocking immune checkpoints may
promote endogenous antitumour
activity
►
PD1: Inhibitory receptor on activated
T-cells, B-cells, NK and myeloid cells.
Inhibition of T-cell activation when
engaged by ligands (PDL1/2)
►
PD1 expressed on T-cells when
exposed to tumour, and associated
with exhaustion. Blocking can restore
Ribas A. N Engl J Med 2012;366:2517-2519.