792 / 1835
Radiation Therapy : a potentially important modifier of the
immune response to tumour
Impact of radiation therapy on the generation
of tumour-specific immunity:
•
Enhanced antigen release
•
Expression of NK2GD ligands
•
Complement deposition
•
Production of type I IFN
•
Increased MHC and neo-antigen expression
•
Induction of immunogenic cell death
Outer cell
membrane
Radiation
Phosphatidylserine
Calreticulin
Cancer
cell
HMGB1
NK2GD ligand
MHCI/
novel peptide
Type I IFN
ATP
Complement
Dendritic cell
Find me, eat me signals
HSP 70, 90