194-195 / 1173
survival of HCT116 colorectal carcinoma cells
(Chu, Dewey et al, 2004)
p21-/-:
⬇
G1 arrest
⬆
survival
p21-/-
14-3-3σ-/-:
⬇
late S/G2 arrest
⬇
survival
14-3-3σ-/-
• The type of cell death has no
relation with sensitivity
• Death and removal of cells after
irradiation may take many d ys or
even weeks