305 / 1173
DNA Repair and Cancer
1. Most anticancer agents work by damaging DNA
2. Changes in DNA repair influence radiosensitivity
Human tumor cells
Human fibroblasts
0
2
4
6
8
10
12
Dose (Gy)
0.001
0.01
0.1
1
Surviving fraction
0
2
4
6
8
10
12
Dose (Gy)
0.001
0.01
0.1
1
Surviving fraction