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cells at intermediate hypoxia levels may
determine the response of fractionated irradiation
0 10 20 30 40 50 60
-10
-9
-8
-7
-6
-5
-4
-3
-2
-1
10
10
10
10
10
10
10
10
10
10
10 0
No Hypoxic Cells
Surviving Fraction
Total Dose (2 Gy Fractions)
10% hypoxic cells with
full reoxygenation
(binary)
10% hypoxic cells with
full reoxygenation
(diffusion)
Wouters and Brown,1997