559 / 1173
Summary of tumor hypoxia
• Mechanisms responsible for tumor hypoxia
• chronic and acute
• Supply, demand, tolerance
• Hypoxia is heterogeneous
• amount, spatial, severity, time
• Hypoxia can promote malignancy
– Tumors become hypoxia tolerant (selection for p53
mutations)
– Hypoxia alters cellular function through transcription,
translation and protein activity