00_MJ_Intro_Budapest16.pptx

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ARCON

A

ccelerated

R

adiotherapy +

C

arbOgen +

N

icotinamide

D

D

D

D

D

S S

S S

S

S

S

S S

S

S

S

S

S

S

S

S

S

S

S

S

D

D

D

D D

D D

D

D

S

S

S

S

S

S

S

S

S S

S

S S

S

S

Tumor cell proliferation

D

S

S

S

S

S

S

S

S

D

D

D

D

D

D

D

D

D D

D

S

S S

S

S

S

S

S

S

S

S

S

S

S

S

D

D

D

D

D

D

D

D

D

D

S

S

S S

S

S

S

S

S

S

S

S

S

S

S

S

S

S

S

S

S

S

S

S

D

D

D

D

D

D

D

D

D

D

D

D

S

S

S S

S

S

S

S

S

S

D

D

D

D

D

D

D D

D

D

D

D

D

S

S

S

S

S

S S

S

S

S

S

S

S

S

S S

S

D S

S

D

D

S

S S

S S

S

S

S

D

D

D

S

S

S

S

D

D

D

D

D

S

S

S

S

S

S

S

S

S

S

S

S

S

S

S

Accelerated fractionation

S

D S

S

D

D

S

S S

S S

S

S

S

D

D

D

S

S

S

S

D

D

D

D

D

S

S

S

S

S

S

S

S S

S

S

S

S

S

S

S

D

stem cell

differentiated cell

Chronic hypoxia

Carbogen

98% O

2

+ 2% CO

2

Nicotinamide

Acute hypoxia