00_MJ_Intro_Budapest16.pptx

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Pentoxifylline, Vitamin E

Delanian et al., JCO 21, 2003, 2545-2550

PTX+VE PTX

+ Placebo

Placebo

+ VE

Placebo

+ Placebo

Radical scavenging/detoxification

Skin fibrosis:

Perpetuating

due to local

hypoxia?