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Optimum intervention strategies required
Ø
precise knowledge of the signaling chains
- cell type/ tissue specific/
tumor
?
Ø
clarification of mechanisms
Ø
validation in suitable animal models
- with clinically relevant endpoints
- with relevant treatment protocols
Ø
proof of selectivity
(tumour studies, same premises)
Ø
Modification cocktails!?
Localize effect?
Long-term effects?