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ESTRO

Protein,

RNA

nitroreductases

e

-

18

F-MISO,

18

F-AZA

oxidation

O

2

-

O

2

18

F-MISO

-

,

18

F-AZA

-

HO

18

F

O

HO

N

N

NO

2

18

F-AZA

tumour cell

diffusion

e

-

NO

2

N

CH

2

18

F

OH

18

F-MISO

N

Tumor hypoxia