953 / 1173
summary: tumor growth delay
• dependent on reliable volume measurement (difficult!)
with ultrasound imaging or bioluminescence more
reliable than manual caliper
• only suitable for few logs of tumor cells (selection)
• reflects growth rate of clonogenic and non-clonogenic
cells
• dependent on growth rate of tumor
- comparison of different tumors difficult
- drugs may change growth rate
(overestimation of efficacy)
- radiation damage of vessels changes growth rate
(tumor bed effect; overestimation of efficacy)