100
0.01
0.1
1
10
1000
1min
10 min
1 h
100 h
10 h
Dose rate (cGy/min)
Time to give 2 Gy
Repair
Redistribution
Reoxygenation
Repopulation
LDR MDR
HDR
Modified from
Steel et al
(1986)
Radiobiological mechanisms underlying the dose rate effect