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Existing Methods (General)
AOAC has 2 Official methods
▪
AOAC SMPR 2014.001
▪
AOAC SMPR 2012.006
USP has the following methods:
▪
USP 38-NF33 Vitamin K2 MK7
▪
HPLC methods for pure preparation tablets capsules
,
,
,
▪
USP 29-NF24 Vitamin K1(Phytonadione)
▪
HPLC method for pure, injectable emulsion, tablets
Regulatory Guidance
Intake recommendations for Vitamin K are provided in the Dietary Reference Intakes (DRIs)
developed by the Food and Nutrition Board (FNB) at the Institute of Medicine of the National
Academies.
Age
Male
Female
Pregnancy
Lactation
Birth to 6 months
2.0 mcg
2.0 mcg
7–12 months
2.5 mcg
2.5 mcg
1–3 years
30 mcg
30 mcg
Adequate intake for Vitamin K
4–8 years
55 mcg
55 mcg
9–13 years
60 mcg
60 mcg
14–18 years
75 mcg
75 mcg
75 mcg
75 mcg
19+ years
120 mcg
90 mcg
90 mcg
90 mcg