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Prognosis of early breast cancer has been greatly improved in the

last four decades

• Landmark trials of adjuvant tamoxifen

• 1970s and 1980s; combination chemotherapy

• Since then, ever more intense and complex regimens, containing a

combination of cytotoxic agents, endocrine agents and/or targeted

agents have become the norm for hundreds of thousands of women

.

19-9-2017