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Conclusions Pre-menopausal ER+ BC

Effectivity aromatase inhibitor + ovarian suppression not convincing

Trend worser overall survival

•Impact ovarian suppression + TAM vs TAM:

–Trend better DFS and OS

–Young age

–Higher risk (initial chemotherapy)

•Don’t forget large influence Qol:

–AR / OFS > TAM + OFS > TAM

19-9-2017