1194 / 1816
L’association aux traitements systémiques
Center, RILA, Adjuvant CT, Boost
CO HO RT phase II study
Breast-conserving surgery, HR+, post-menopause
Arm A
Radiation-induced lymphocyte apoptosis (RILA) test
No adjuvant CT
Adjuvant CT
2
nd
RILA test
Stratification
Adjuvant RT
Randomization
Arm B
Letrozole 2.5 mg/day
5 years
Adjuvant RT
Letrozole 2.5 mg/day
5 years
Azria et al. Lancet Oncol 2010