1196 / 1816
L’association aux traitements systémiques
• COHORT is the first randomized trial evaluating RT and HT (letrozole)
concurrently
or
sequentially
• In both arms,
No difference of
acute
and
late
skin toxicity
• Interestingly, late subcutaneous fibrosis is strongly influenced by intrinsic
radiosensitivity evaluated by RILA
Longer F-up
is warranted for:
- Skin toxicity evaluation
- Lung fibrosis evaluation (CT Scan, functional tests)
- Cardiac events (3D planning dosimetry, Heart DVH)
- SNP screening
Conclusions
Azria et al. Lancet Oncol 2010