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Neo-adjuvant/Primary chemotherapy (=NAC)
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Concept developed concurrently with adjuvant
chemotherapy in the 1970s
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Neoadjuvant systemic treatment is an established part of
the management of large, potentially operable, and
locally advanced breast cancers
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Converts a previously unresectable, locally advanced
breast cancer to an operable tumor
•
Has evolved since to use in operable breast tumours