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Conundrum of PST: discussion & conclusions
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Primary systemic treatment is increasingly used
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Radiation therapy is indicated for most patients
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The role of surgery is questioned
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High-level evidence is missing
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Available evidence supports basing indications for RT on
disease extent at diagnosis
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Individualisation based on tumour- and patient-related
factors can be done, combined with the response to PST
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For fine-tuning we need results from on-going and future
clinical trials