1594 / 1816
Limitations of Randomized Trials for Studying
Late Effects of Breast Cancer Radiotherapy
• Old fashioned radiotherapy techniques and little
detailed information on regimens, so accurate
doses to organs at risk cannot be calculated
• Incidence information not usually available for
heart disease (and only sometimes for second
cancer)
• Women at increased risk of heart disease or
lung cancer tend not to be included in trials
6