1592 / 1816
Taylor et al on behalf of EBCTCG, JCO 2017; 35:1641
Number of events
Rate ratio
(95% CI)
P value
RT
No RT
Excess with
RT
Death without breast cancer recurrence
Heart disease
705
548
143
1.30 (1.15—1.46)
<0.0001
Non-breast cancer
475
375
67
1.19 (1.03—1.37)
0.02
Other specified causes
638
629
6
1.01 (0.90—1.14)
0.83
Second cancer incidence without prior breast cancer recurrence
Leukaemia
43
23
17
1.71 (1.05—2.79)
0.03
Lung, years 0-9
71
60
5
1.08 (0.76—1.53)
0.66
Lung, years 10+
94
40
47
2.10 (1.48—2.98)
<0.0001
Oesophagus
23
10
13
2.42 (1.19—4.92)
0.01
Contralateral breast
881 673
130
1.20 (1.08—1.33)
0.0006
Effect of Radiotherapy on
Non-breast-cancer Mortality
and on
Incidence of Second Cancers
before any Recurrence of Breast Cancer
(40,781 women in 75 trials of radiotherapy versus no radiotherapy)