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Population-based case-control study of
major coronary events (MCEs)
•
Population: Women irradiated for breast cancer identified from
population-based cancer registries
(Denmark: 1977-2006, Stockholm:
1958-2002)
•
963 Major Coronary Events (MCEs) before breast cancer recurrence
identified from nationwide disease registers
•
1205 controls also irradiated for breast cancer but without
recurrence identified from nationwide disease registers
(matched for
country, age, calendar period & time since cancer diagnosis)
•
Information from oncology records obtained by
research nurses
(tumor characteristics, medical history, including prior heart disease)
•
Individual radiotherapy treatment information obtained by
research
nurses
NEJM 2013; 368:987-98