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Pulmonary toxicity – Interstitial pneumonitis
Complaints:
• Pneumonitis/fibrosis, acute pleuritic pain, hypersensitivity
• Pulmonary edema, dyspnea, dry cough, fatigue, fever
• Appears gradually over several weeks
• Differential diagnosis: Infection, pulmonary embolus, cardiogenic edema,
lower ejection fraction, progressive tumor
• Pathology: endothelial cell swelling, necrosis of pneumocytes, generalized
fibrosis in end-stage
• Treatment: supportive care, steroids
19-9-2017