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Fatigue
‘a distressing, persistend, subjective sense of physical, emotional,
and/or cognitive tiredness or exhaustion that is not proportional to
recent activity and interferes with usual functioning’’
Incidence during treatment 70 – 100%
Chronic fatigue
Incidence 0 - 60%*
Possible mechanisms: Hormonal dysfunction, dysregulation
cytokines, dysruption biorhythm
Predictors: depression, pain,poor sleep, menopausal symptoms#
More studies are needed to evaluate the burden of this side effect
*Broeckel (1998), Bower(2000), Servaes(2002), Cella(2001)
#Lawrence 2004