360-361 / 1816
PAPBI-2 phase III trial
Preoperative Accelerated Partial Breast Irradiation: open in Holland
Preop PBI vs postop PBI (5 x 5.7 Gy)
Endpoint:
cosmetic outcome
Side study:
tumour response on RT
Hypothesis:
fair/poor cosmesis 20%
vs 10%
Aim: 500
patients
Inclusion criteria:
Female patients ≥ 51 years
cT1-2N0 (≤3 cm)
Grade I or II (biopsy)
Histologically proven ductal invasive carcino
Unifocal lesion on mammogram and MRI
Exclusion criteria:
Lobular invasive carcinoma
Pure DCIS without invasive tumour
Triple negative tumours
Lymphvascular invasion in biopsy