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Partial breast irradiation in DCIS
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DCIS is considered suitable for PBI, if acc. to RTOG 9804 low risk:
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Screen-detected, Grade 1-2, ≤ 2.5 cm, free margins ≥ 3 mm
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IBTR risk w/o RT: 6.7% at 7.2 yr (RTOG 9804)
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IBTR risk w/o RT: 14.2% at 12 yr (ECOG E 5194)
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Applying these criteria to APBI with mammosite:
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40 patients: 5 yr risk IBTR 0%
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Pooled analysis DCIS treated with mammosite:
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300 patients, 5 yr IBTR 2.5%
“These patients could also be offered endocrine Rx or observation alone”
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RCTs PBI vs WBRT for DCIS are underway..!