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Summary
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RT reduces LR rate after BCS with a factor 2, but effect on OS
doubtful/ limited to subgroups.
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Probably we can discriminate 3 risk groups:
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High risk:
RT is indicated, yields survival benefit – and boost may
give additional benefit
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Intermediate risk:
RT is to be discussed with patients, and burden
can be reduced by hypofractionation and/or partial breast RT
•
Low risk:
RT can be withheld at all !
•
How to discriminate these subgroups ?