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Methods
•
Use of 2 important datasets
1.
EORTC boost no boost trial:
N = 1282, all margins with < 10 mm, no EDCIS, including LR rates &
margin widths
2.
MARGINS database:
Database of 60 patients, with pre-operative MRI matched with pathology
of wide local excision specimens
Described the relation between residual volume of disease and margin
width.