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Methods

1.

Determine residual tumor volume in wide local excision specimens in

MARGINs database in relation to distance of invasive primary tumor,

i.e. margin width

2.

Calculate the TCP (LR) for different residual volumes using Webb-

Nahum model

3.

Combine 1 and 2 to calculate the LR as a function of margin width

4.

Compare the estimated LR with the observed LR rate in the EORTC

dataset, as a function of margin width