812-813 / 1816
Is this necessary?
Node
Positive
Halsted
Mx/RT
Node
negative
Halsted
MX/RT
Mx only
NSABP B-04, (started in 1971), study of
Fisher and colleagues, (2002)
Women randomised according to
whether clinically node positive or
negative.
No patients had adjuvant systemic
therapy and tumours were large by
modern standards
40% of the ‘clinically node negative’
cases had +ve nodes in the clearance
group