1172-1173 / 2437
Evolution of germinoma therapy
chemotherapy
radiotherapy
radiotherapy
cranio-spinal axis RT 36 Gy + boost to tumour site 14Gy
(
total tumour dose 50Gy)
Carboplatin
Etoposide
Ifosfamide
whole ventricular or tumour site RT
(
total tumour dose 40Gy)
cranio-spinal axis RT 24Gy + boost to tumour site 16Gy
(
total tumour dose 40Gy)
dose reduction
whole brain or whole ventricular RT 24Gy + boost to tumour site 16Gy
(
total tumour dose 40Gy)
chemotherapy & volume reduction
German MAKEI studies
volume reduction
Cranial germinoma