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Calaminus

et al 2013 Neuro-oncology;15(6):788-96

SIOP CNS GCT 96 - germinoma

Cranial germinoma

investigator choice

non-metastatic

metastatic

chemotherapy

local RT

40Gy in 25F

CSA-RT

24Gy in 15F

& local

boost 16Gy in 10F

CSA-RT

24Gy in 15F

& local

boost 16Gy in 10F

chemotherapy

125 pts

chemotherapy

alternating Carboplatin/Etoposide

and Carboplatin/Ifosfamide

CSA-RT

- craniospinal axis radiotherapy