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Calaminus
et al 2013 Neuro-oncology;15(6):788-96
SIOP CNS GCT 96 - germinoma
Cranial germinoma
investigator choice
non-metastatic
metastatic
chemotherapy
local RT
40Gy in 25F
CSA-RT
24Gy in 15F
& local
boost 16Gy in 10F
CSA-RT
24Gy in 15F
& local
boost 16Gy in 10F
chemotherapy
125 pts
chemotherapy
alternating Carboplatin/Etoposide
and Carboplatin/Ifosfamide
CSA-RT
- craniospinal axis radiotherapy