1194-1195 / 2437
Cranial germinoma
Evolution of germinoma therapy
chemotherapy
radiotherapy
radiotherapy
cranio-spinal axis 36 Gy + boost to tumour site 14Gy
(
total tumour dose 50Gy)
Carboplatin
Etoposide
Ifosfamide
tumour site alone
(
total tumour dose 40Gy)
cranio-spinal axis 24Gy + boost to tumour site 16Gy
(
total tumour dose 40Gy)
dose reduction
volume reduction
whole brain or whole ventricular RT 24Gy + boost to tumour site 16Gy
(
total tumour dose 40Gy)
chemotherapy & volume reduction
SFOP-TMG-90 French study