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How to confirm the diagnosis
• Lumbar puncture: dissemination in the CSF in 20-30% of the
patients with newly diagnosed PCNSL
=> Confirmation of a malignant B cell clone (FACS) or clonal
IgH rearrangement using PCR
• Stereotactic biopsy: do not administer steroids before!
• Tumor resection does not affect survival – really…?
Staging:
• Slit lamp examination (ocular involvement in 10-15%)
• CT scan chest and abdomen, bone marrow biopsy
• HIV testing