1334-1335 / 2437
Autor
n
RT
Chx
Age
Results
Greenberg
et al.,2001
17 CSI + local
boost
Packer (n=10)
POG (n=7)
Median: 23
(18-47)
EFS – (median)/
(MST)
:
Packer-Gr. : 26 Mon./
(36 Mon.)
POG-Gr. : 48 Mon./
(57 Mon. )
Coulbois et
al., 2001
22 n.A.
n.A.
n.A.
5- y PFS: 63.1%
5- y OS : 81.3%
Brandes et
al., 2003
36 CSI + boost
(36,0 Gy /
54.8 Gy)
Chx. only
“high risk”
18 years
PFS 5 – J.: M0 75% vs. M+ 45%
PFS 5 – J. “standard risk” 76%
vs.“high risk” 61%
Louis et al.,
2002
24 CSI +local
boost
Chx. in 6 Pat.
after relapse
16 years
5 – y. OS: 82%
Spreafico et
al., 2005
23 A : 36 /55 Gy
B : HART
39,1 / 60 Gy
Sandwich
Med. 26 y
(18-41 y.)
5 – J. DFS : 65%
OS: 73%
HART all pts. med 39 Mon. OS
Padovani et
al., 2007
253 CSI
<30/> 30 Gy
PF<50/>50 Gy
Sandwich
Med. 26 y
(18-41 y.)
5 – J. DFS : 65%
OS : 73%
HART all pts. med 39 Mon. OS
Friedrich et
al., 2013
70 CSI 35,2
PF : 55 Gy
Packer-Chx.
49 Pts.
Med. 28,5y
(21-50 y.)
4 – J. EFS : 68% (only M 0)
OS : 89%
Medulloblastoma Different Studies