1336-1337 / 2437
Autor
n
RT
Chx
Age
Results
Brandes
et al., 2007
36 CSI + boost
(36,0 Gy /
54.8 Gy)
Chx. only
“high risk”
18 years PFS 5 – y.: M0 78% vs. M+ 61%
PFS 5 – y. “standard risk” 80%
vs.“high risk” 69%
OS 5 –y.: 80% low risk vs.73%high
risk
Medulloblastoma Different Prospective Studies
N=36 pts. 10 low risk
Radiotherapy alone
26 high risk
Upfront CT + RT + adjuvant CT
22/26 upfront chemotherapy: 26 MOPP based
6 cisplatin based
RT Posterior Fossa 54.8Gy / CSI 36 Gy
Maintenance CT since 1995: cisplatin 25 mg/m2 day 1-4
Etoposide 40 mg/m2 day 1-4
Cyclophosphamide 1000 mg/m2 day 4